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Institut für Genetik
Universität Bonn
Karlrobert-Kreiten-Str. 13
53115 Bonn
Mo-Fr   09:30 - 13:00
Tel.: 0228-73-4210
Fax: 0228-73-4263
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Publikationen Prof Dr. Walter Witke

Relevante Publikationen der letzten Jahre


Wei-Ting Kuo, Li Zuo, Matthew A.Odenwald, Shariq Madha, Gurminder Singh, Christine B.Gurniak, Clara Abraham, Jerrold R.Turner. The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair. Gastroenterology 2021 Aug 31;S0016-5085(21)03465-X.
Schaks M, Reinke M, Witke W, Rottner K. Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2. Cells. 2020 May 29;9(6):1355. doi: 10.3390/cells9061355.
Salz A, Gurniak CB, Jönsson F, Witke W. Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus. Journal of Cell Science 2020 133: jcs238048 doi: 10.1242/jcs.238048 Published 6 March 2020.
Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F. ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron. 2019 Jul 30. pii: S0896-6273(19)30633-6.
Aihara E, Medina-Candelaria NM, Hanyu H, Matthis AL, Engevik KA, Gurniak CB, Witke W, Turner JR, Zhang T, Montrose MH. Cell injury triggers actin polymerization to initiate epithelial restitution. J Cell Sci. 2018 Aug 20;131(16). pii: jcs216317. doi: 10.1242/jcs.216317.
Luscieti S, Galy B, Gutierrez L, Reinke M, Couso J, Shvartsman M, Di Pascale A, Witke W, W Hentze M, Pilo Boyl P, Sanchez M. The actin-binding protein profilin 2 is a novel regulator of iron homeostasis. Blood. 2017 Oct 26;130(17):1934-1945. doi: 10.1182/blood-2016-11-754382. Epub 2017 Aug 3.

Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB. Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. Cell Death Dis. 2017 Oct 5;8(10):e3063.
Megaw R, Abu-Arafeh H, Jungnickel M, Mellough C, Gurniak C, Witke W, Zhang W, Khanna H, Mill P, Dhillon B, Wright AF, Lako M, Ffrench-Constant C. Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models. Nat Commun. 2017 Aug 16;8(1):271.
Zalli D, Neff L, Nagano K, Shin NY, Witke W, Gori F, Baron R. The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro. J Bone Miner Res. 2016 Sep;31(9):1701-12.
Kanellos G, Zhou J, Patel H, Ridgway RA, Huels D, Gurniak CB, Sandilands E, Carragher NO, Sansom OJ, Witke W, Brunton VG, Frame MC. ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival. Cell Rep. 2015 Dec 1;13(9):1949-64.
Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, Brückner BR, Alexopoulos I, Czopka T, Jung SY, Rhee JS, Janshoff A, Witke W, Schaap IA, Lyons DA, Simons M. Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. Dev Cell. 2015 Jul 27;34(2):139-51.
Escuin S, Vernay B, Savery D, Gurniak CB, Witke W, Greene ND, Copp AJ. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure. J Cell Sci. 2015 Jul 15;128(14):2468-81.
Wolf M, Zimmermann AM, Görlich A, Gurniak CB, Sassoè-Pognetto M, Friauf E, Witke W, Rust MB. ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis. Cereb Cortex. 2015 Sep;25(9):2863-75.
Zimmermann AM, Jene T, Wolf M, Görlich A, Gurniak CB, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB. Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics. Biol Psychiatry. 2015 Jul 15;78(2):95-106.
Gurniak CB, Chevessier F, Jokwitz M, Jönsson F, Perlas E, Richter H, Matern G, Pilo Boyl P, Chaponnier C, Fürst D, Schröder R, Witke W. Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. Eur J Cell Biol. 2014 Feb 11. pii: S0171-9335(14)00028-4.
Flynn, K., Neukirchen, D., Jacobs, S., Tahirovic, S., Garvalov, BK., Meyn, L.,Gurniak, CB.,Wedlich-Söldner, R., Small, JV., Witke, W., Bradke, F.ADF/cofilin-mediated actin turnover directs neurite formation in the developing brain through its severing activity. Neuron. 2012 Dec 20;76(6):1091-107.
Goodson, M., Rust, MB., Witke, W., Bannerman, D., Mott, R., Ponting, CP., Flint, J. Cofilin-1: a modulator of anxiety in mice.  PLoS Genetics, 8(10):e1002970
Rust, MB, Kullmann, JA., Witke, W. Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum. Cell Adh Migr, 6(1): 13-7
Jönsson F, Gurniak CB, Fleischer B, Kirfel G, Witke W. Immunological Responses and Actin Dynamics in Macrophages Are Controlled by N-Cofilin
but Are Independent from ADF. PLoS ONE 7(4): e36034. doi:10.1371/journal.pone.0036034
Rehklau K, Gurniak CB, Conrad M, Friauf E, Ott M, Rust MB. ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling. Cell Death Differ. 2011 Dec 2. doi: 10.1038/cdd.2011.180.
Görlich, A., Wolf, M., Zimmermann, AM., Schober, D., Böttcher, R.T., Sassoe-Pognetto, M., Friauf, E., Witke, W., Rust, MB. Preserved morphology and physiology of excitatory synapses in profilin1 deficient mice. PLoS One.

Kullmann, JA., Neumeyer, A., Gurniak, CB., Friauf, E., Witke, W., Rust, MB. Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons. EMBO Rep., Nov. 11: 1-8.
Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RPA. Gelsolin-Independent Podosome Formation in Dendritic Cells. PLoS ONE 6(7): e21615. doi:10.1371/journal.pone.0021615
Kuure S, Cebrian C, Machingo Q, Lu BC, Chi X, Hyink D, D'Agati V, Gurniak C, Witke W, Costantini F. Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis. PLoS Genet. 2010 Oct 28;6(10):e1001176.
Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010 Sep 9;116(10):1767-75. Epub 2010 Jun 7.PMID: 20530287

Garg P, Verma R, Cook L, Soofi A, Venkatareddy M, George B, Mizuno K, Gurniak C, Witke W, Holzman LB. Actin depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. J Biol Chem. 2010 May 15. [Epub ahead of print]PMID: 20472933 

Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Görlich A, Sassoè-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W. Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics. EMBO J. 2010 Jun 2;29(11):1889-902. Epub 2010 Apr 20.PMID: 20407421 [PubMed - in process]Related citations

Gonçalves AF, Dias NG, Moransard M, Correia R, Pereira JA, Witke W, Suter U, Relvas JB. Gelsolin is required for macrophage recruitment during remyelination of the peripheral nervous system. Glia. 2010 Apr 15;58(6):706-15.PMID: 20014276 [PubMed - indexed for MEDLINE]Related citations

Grisanti L, Corallini S, Fera S, Muciaccia B, Stefanini M, Witke W, Vicini E. Inactivation of Numb and Numblike in spermatogonial stem cells by cell-permeant Cre recombinase. Differentiation. 2009 Sep-Oct;78(2-3):131-6. Epub 2009 Jun 21.PMID: 19541401 [PubMed - indexed for MEDLINE]Related citations

Bowerman M, Anderson CL, Beauvais A, Boyl PP, Witke W, Kothary R. SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis. Mol Cell Neurosci. 2009 Sep;42(1):66-74. Epub 2009 Jun 1.PMID: 19497369 [PubMed - indexed for MEDLINE]Related citations

Oikonomou N, Thanasopoulou A, Tzouvelekis A, Harokopos V, Paparountas T, Nikitopoulou I, Witke W, Karameris A, Kotanidou A, Bouros D, Aidinis V. Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis. Thorax. 2009 Jun;64(6):467-75. Epub 2009 Feb 12.PMID: 19213772 [PubMed - indexed for MEDLINE]Related citations

Maniatis NA, Harokopos V, Thanassopoulou A, Oikonomou N, Mersinias V, Witke W, Orfanos SE, Armaganidis A, Roussos C, Kotanidou A, Aidinis V. A critical role for gelsolin in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2009 Oct;41(4):426-32. Epub 2009 Feb 6.PMID: 19202007 [PubMed - indexed for MEDLINE]Related citations

Napoli I, Mercaldo V, Pilo Boyl P, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C. The Fragile X mental retardation protein represses activity-dependent mRNA translation through Cyfip1/Sra1, a new neuronal 4E-BP. Cell, 2008, 134(6), 1042-54.

Kursula P, Kursula I, Massimi M, Song YH, Downer J, Stanley WA, Witke W, Wilmanns M. High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: The formin homology domain of mDia1 and the proline-rich doman of VASP.  J. Mol. Biol., 2008, 375, 270-290.

Bellenchi GC*, Gurniak C*, Perlas E, Middei S, Ammassari-Teul M, Witke, W. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes&Development, 2007, 21(18), 2347-57.  (* equal contributing first authors)

Pilo Boyl P, Di Nardo A, Kneussel M, Sassoe-Pognetto M, Panzanelli P, Witke W. Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behaviour. EMBO J., 2007, 26(12), 2991-02.

Gurniak C and Witke W. GFP-actin expressing mice: HuGE, a novel GFP-actin expressing mouse line for studying cytoskeletal dynamics. Eur. J. Cell Biol. 2007, 86(1), 3-12.

Spinardi L and Witke W. Gelsolin and Diseases. Subcell. Biochem. 2007, 45, 55-69.

Gareus R, Di Nardo A, Witke W. Profilin 2 and SH3-containing ligands compete for binding to dynamin I and regulate endocytosis. J. Biol. Chem., 2006, 281(5), 2803-11.

Aidinis V, Carninci P, Armaka M, Witke W, Harokopos V, Pavelka N, Koczan D, Argyropoulos C, Thwin MM, Moller S, Kazunori W, Gopalakrishnakone P, Ricciardi-Castagnoli P, Thiesen HJ, Hayashizaki Y, Kollias G. Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis. PloS Genetics, 2005, 1(4), 455-66.

Gurniak C, Perlas E, Witke W. The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev. Biology, 2005, 278(1), 231-41.

Neuhoff H, Sassoe-Pognetto M, Panzanelli P, Mueller C, Witke W, Kneussel M. The actin binding protein profilin 1 is localized at synaptic sites in an activity-regulated manner. Eur. J. Neuroscience, 2005, 21(1), 15-25.

Marazziti D, Golini E, Mandillo S, Magrelli A, Witke W, Matteoni R, Tocchini-Valentini GP. Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson’s disease-associated GPR37/PAEL receptor.  Proc. Natl. Acad. Sci. USA, 2004, 101(27), 10189-94.

Witke W. The role of profilin complexes in cell motility and other cellular processes. Trends in Cell Biology, 2004, 14(8), 461-69