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Institut für Genetik
Universität Bonn
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Publications Research Unit Immunbiologie

Publications Prof. Dr. Norbert Koch

Relevant publications in recent years


Kämper N., Kessler J, Temme S, Wegscheid C, Winkler J, et al. (2012) A Novel BAT3 Sequence Generated by Alternative RNA Splicing of Exon 11B Displays
Cell Type-Specific Expression and Impacts on Subcellular Localization. PLoS ONE 7(4): e35972. doi:10.1371/journal.pone.0035972


Kämper, N., Franken, S., Temme, S., Koch, S., Bieber, T. and N. Koch. 2011. Gamma Interferon-Regulated Chaperone Governs Human Lymphocyte Antigen Class II Expression. FASEB J published online

Koch, N., Zacharias, M., König, A., Temme, S., Neumann, J., and Springer, S. 2011. Stoichiometry of HLA Class II-Invariant Chain Oligomers. PLoS ONE 6(2): e17257.doi:10.1371/journal.pone.0017257.


Temme S., A.-M. Eis-Hübinger, A.D. McLellan, and N. Koch. 2010. The Herpes Simplex Virus-1 encoded Glycoprotein B Diverts HLA-DR Into the Exosome Pathway. J. Immunol. 184: 236-243.


Ting, Y.T., Temme, S., Koch, N., and McLellan, A.D. 2009. A new monoclonal antibody recognizing a linear determinat on the HLA-DR chain N-terminus. Hybridoma. 28: 423-429.


Haylett, R.S., Koch, N., and Rink, L. 2009. MHC class II molecules activate NFAT and the ERK group of MAPK through distinct signalling pathways in B cells. Eur. J. Immunol. 39:1947-1955.


Dlaske, H., Karaüzüm, H., Monzon-Casanova, E., Rudolf, R., Starick, L., Müller, I., Wildner, G., Diedrichs-Moehring, M., Koch, N., Miyoshi-Akiyama, T., Uchiyama, T., Wonigeit, K., Fleischer, B., Overbeck, S., Rink, L., and Herrmann, T. 2009. Superantigen-presentation by rat MHC class II molecules RT1.BI and RT1.DI. Immunology. 128: 572-581.


Saunderson, S.C. Schuberth, P.C., Dunn, A.C. Miller, L., Hock, B.D., MacKay, P.A., Koch, N., Jack, R.W. and McLellan, A.D. 2008. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J. Immunol.180: 8146-8152.


Nagaraj S., Neumann, J., Winzen, B., Frank, S., Ziske, C., Sievers, E., Koch, N. and Schmidt-Wolf, G.H. 2008. Pancreas carcinoma antigen fused to invariant chain elicits T cell response and tumor growth inhibition. Pancreas 37: 321-327.

Koch N, McLellan AD, Neumann J. A revised model for invariant chain-mediated assembly of MHC class II peptide
Trends Biochem Sci. 2007 Dec;32(12):532-7

Neumann, J., König, A. and Koch, N. Detection of Aberrant Assembly of DM with MHC Class II Subunits in the Absence of Invariant Chain. Int Immunol., 2007 Jan;19(1):31-9

Neumann, J., and Koch, N. 2006 A novel domain on HLA-DRb chain regulates the chaperone role of invariant chain.
J. Cell Sci. 119: 4207-4212

P.A. MacKay, S. Leibundgut-Landmann, N. Koch, A.C. Dunn, W. Reith, R.W. Jack, A. D. McLellan. 2006. Circulating, soluble forms of Major Histocompatibility Antigens are not exosomen associated. Eur. J. Immunol. 36: 2875-2884

Neumann, J., and Koch, N. 2005. Assembly of major histocompatibility complex class II subunits with invariant chain.
FEBS Lett. 579:6055-6059.

Neumann, J. 2005. Novel antibody tags from the rat lysosomal protein RT1.DM for immunodetection of recombinant proteins. J Immunol Methods.301:66-76.

 Klein E, Koch S, Borm B, Neumann J, Herzog V, Koch N, Bieber T. 2005. CD83 localization in a recycling compartment of immature human monocyte-derived dendritic cells.
Int Immunol.17:477-87.

Schneiders, A., Thiel, S., Winkler, J., Moller, P., Koch, N. 2005. Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide. Vaccine 23:2540-2550.


Laurie, K.L., La Gruta, N.L., Koch, N., van Driel, I.R. and Gleeson, P.A. 2004. Thymic Expression of a Gastritogenic Epitope Results in Positive Selection of Self-Reactive Pathogenic T Cells. J. Immunol. 172: 5994-6002.

Neumann, J., Eis-Hübinger, A.M. and Koch, N. 2003. Herpes Simplex Virus Type 1 Targets the MHC Class II Processing Pathway for Immune Evasion. J. Immunol. 171(6):3075-3083

Leverkus, M., McLellan, A.D., Heldmann, M., Eggert, A.O., Koch, N., Bröcker, E-B., and Kämpgen, E. 2003. MHC class II-mediated apoptosis in dendritic cells: a role for membrane-associated and mitochondrial pathways. Int. Immunol. 15:1-14.

Sievers, E., Neumann, J., Raftery, M., Schönrich, G., Eis-Hübinger, A. M. and Koch, N. 2002. Glycoprotein B from strain 17 of Herpes simplex type I contains an invariant chain homologous sequence that binds to MHC class II molecules. Immunology 107: 129-135.

Neumann, J., Schach N. and Koch, N. 2001. Glycosylation signalsthat separate the trimerization from the MHC class II-binding domain controlintracellular degradation of invariant chain.2001. J.Biol. Chem. 276: 13469-13475.

Diebold S.S., Cotten M., Koch N., and Zenke, M. Presentationof MHC Class I and Class II epitopes by genetically modified dendriticcells. 2001. GeneTherapy. 8: 487-493.

Hitzel, C., Kanzler, H., König, A. Kummer M.P., Brix K., Herzog V. and Koch, N. 2000. Thyroglobulin Type I-Like Domains in Invariant Chain Fusion Proteins Mediate Resistance to Cathepsin L Digestion. FEBS Letters 485: 67-70

Koch, N., van Driel, I.R. and Gleeson P.A. 2000. Highjackinga chaperone: Manipulation of the MHC class II presentation pathway. Immunol.Today 21: 546-550.

Carstens, C., Newman D.K., Bohlen, H., König, A. and Koch, N. 2000 Invariant chains with the class II binding site replaced by a sequence from influenza virus matrix protein constrain low affinity sequences to MHCII presentation. Int. Immunol. 12: 1561-1568.

Sponaas, A.-M., Carstens, C., and Koch, N.  1999. C-terminal Extension of the MHC Class II Associated Invariant Chain by an Antigenic Sequence Triggers Activation of Naive T Cells. Gene Therapy 6: 1826-1834.

Hitzel, C., Grüneberg, U., van Ham, M., Trowsdale, J. and Koch,N. 1999. SDS Resistant HLA-DR "Superdimer" Bands are in some Cases Class II Heterodimers Bound to Antibody. J. Immunol. 162: 4671-4676.

Siebenkotten, I.M. , Carstens, C. and Koch, N. 1998 Identification of a Sequence that Mediates Promiscuous Binding of Invariant Chain to Major Histocompatibility Complex Class II Allotypes. J. Immunol. 160: 3355-3362.

Serwe, M., Reuter, G., Sponaas, A., Koch, S. and Koch, N. 1997. Both invariant chain isoforms Ii31 and Ii41 promote class II antigen presentation. Intern. Immunol. 9: 983-991.

Klagge, I., Kopp, U., and Koch, N. 1997. Granolycyte-Macrophage Colony Stimulating Factor Elevates Invariant Chain Expression in Immature Myelomonocytic Cell lines.Immunology 91: 114-120.

N.Koch 1997. Die Steuerzentrale des Immunsystems. (Der Molekulare  Mechanismus der Antigenprozessierung). Biologie in Unserer Zeit. 3: 161-168. 

Gedde-Dahl, M., Freisewinkel, I., Staschewski, M., Schenck, K., Koch, N. and Bakke, O. 1997. Exon 6 is essential for invariant chain trimerization and induction of large endosomal structures. J.Biol. Chem. 272: 8281-8287.

Hitzel, C. and N. Koch. 1996. The invariant chain derived fragment CLIP is an efficient in vitro inhibitor of  peptide binding to MHC class II molecules. Mol. Immunol. 33: 25-31.

Bertolino, P., M. Staschewski, M-C. Trescol-Biemont, I.M.Freisewinkel, K. Schenck, I. Chretien,  F. Forquet, D. Gerlier, C. Rabourdin-Combe, and N. Koch. 1995 Deletion of a C-terminal sequence of the class II associated invariant chain abrogates oligomer formation and class II antigen presentation. J. Immunol. 154: 5620-5629.

Henne, C., F. Schwenk, N. Koch, and P. Möller. 1995 Surface expression of the invariant chain (CD74) is independent of concomitant expression of major histocompatibility complex class II antigens. Immunol. 84: 177-182.

Hitzel, C., P. van Endert, and N. Koch. 1995. Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain. J. Immunol. 154: 1048-1056.

Koch, N., G. Moldenhauer, and P. Möller, 1994. MHC class II processing pathway and a role of surface invariant chain. In: Antigen processing and presentation (Eds. Humphreys and S.K. Pierce). Acad. Press NY: p217-226. 

Freisewinkel, I.M., K. Schenck, and N. Koch. 1993. The segment of invariant chain that is critical for association with MHC class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc. Natl. Acad. Sci. USA. 90: 9703-9706.

Bertolino, P., F. Forquet, S. Pont, N. Koch. D. Gerlier, and C. Rabourdin-Combe. 1991. Correlation between invariant chain expression level and capability to present antigen to MHC class II-restricted T cells. Internat. Immunol. 3: 435-443.

Kämpgen, E., N. Koch, F. Koch, P. Stöger, C. Heufler, G. Schuler, and N. Romani. 1991. Class II major histocompability complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc. Natl. Acad. Sci. USA. 88: 3014-3018.

Koch, N., and B. Stockinger. 1991. Molecules that modify antigen recognition. Curr. Opinion Immunol. 3: 10-15.

Koch, N., G. Moldenhauer, W. Hofmann, and P. Möller. 1991.  Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74). J. Immunol. 147: 2643-2651.

Koch, N., U. Pessara. K. Schenck, and Ch. Wraight. 1991. Molecular analysis of the class II-associated invariant chain. In: CRC Press, Antigen processing and recognition (Ed. J. McCluskey): 215-227. 

Wraight, C.J., P. van Endert, P. Möller, J. Lipp, N.R. Ling, I.C.M. MacLennan, N. Koch, and G. Moldenhauer. 1990. Human MHC class II invariant chain is expressed on the cell surface. J. Biol. Chem. 265: 5787-5792.

Pessara, U., and N. Koch. 1990. Tumor necrosis factor alpha regulates expression of the MHC class II-associated invariant chain by binding of an NF-xB-like factor to a promoter element. Mol. Cell. Biol. 10: 4146-4154.

Koch, N., J. Lipp. U. Pessara, K. Schenck, C. Wraight, and B. Dobberstein. 1989. MHC class II invariant chain in antigen processing and presentation. TIBS 14: 383-386.

Stockinger, B., U. Pessara, R.H. Lin, J. Habicht, M. Grez, and N. Koch. 1989. A role of Ia-associated invariant chains in antigen processing and presentation. Cell 56: 683-689.

Koch, N. 1988. Immunochemical characterization of the Ia associated invariant chain. In: Post-translational modifications of proteins by lipids. A laboratory manual. (Eds. U. Brodbeck and C. Bordier). Springer Verlag Berlin. 1988: p119-122. 

Pessara, U., F. Momburg, and N. Koch, 1988. Cooperative effect of interferon gamma and tumor necrosis factor alpha on the induction of the class II antigen-associated invariant chain expression. Eur. J. Immunol. 1988. 18: 1719-1726.

Koch, N. 1988. Posttranslational modifications of the Ia- associated invariant protein p41 after gene transfer. Biochemistry 27: 4097-4102

Koch, N., W. Lauer, J. Habicht, and B. Dobberstein. 1987. Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin. EMBO J. 6: 1677-1683.

Koch, S., A. Schultz, and N. Koch. 1987. The production of recombinant HLA-DR beta and invariant chain polypeptides by cDNA expression in E.coli. J. Immunol. Meth. 103: 211-220.

Landais, D., B.N. Beck, J.-M. Buerstedde, S. Degraw, D. Klein, N. Koch, D. Murphy, M. Pierres, T. Tada, K. Yamamoto, C. Benoist, and D. Mathis. 1986. The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants. J. Immunol. 137: 3002-3005

Momburg, F., N. Koch, P. Möller, G. Moldenhauer, and G.J. Hämmerling. 1986. In vivo induction of H-2K/D antigens by recombinant interferon. Eur. J. Immunol. 16: 551-557.

Koch, N., and G.J. Hämmerling. 1986. The HLA-D-associated invariant chain binds palmitic acid at the cysteine adjacent to the membrane segment. J. Biol. Chem. 261: 3434-3440.

Momburg, F., N. Koch, P. Möller, G. Moldenhauer, G.W. Butcher, and G.J. Hämmerling. 1986. Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with interferon gamma. J. Immunol. 136: 940-948.

Koch, N., and G.J. Hämmerling. 1985. The Ia-associated invariant chain is fatty acylated before addition of sialic acid. Biochemistry. 24: 6185-6190.

van Driel, I.R., J.W. Goding, and N. Koch. 1985. Plasma cell antigen PC-1 and the transferrin receptor in mouse, rat, and hamster: Serologic and biochemical analyses. J. Immunol. 134: 3987-3993.

Graf, L., N. Koch, and V. Schirrmacher. 1985. Expression of Ia antigens in a murine T-lymphoma variant. Mol. Immunol. 22: 1371-1377.

Yamamoto, K., N. Koch, M. Steinmetz, and G.J. Hämmerling. 1985. One gene encodes two distinct Ia-associated invariant chains. J. Immunol. 134: 3461-3467.

Yamamoto, K., G. Floyd-Smith, U. Francke, N. Koch, W. Lauer, B. Dobberstein, R. Schäfer, and G.J. Hämmerling. 1985. The gene encoding the Ia-associated invariant chain is located on chromosome 18 in the mouse. Immunogenetics 21: 83-90.

Singer, P.A., W. Lauer, Z. Dembic, W.E. Mayer, J. Lipp, N. Koch, G.J. Hämmerling, J. Klein, and B. Dobberstein. 1984. Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone. EMBO J. 3: 873-877.

Koch, N., G.H.W. Wong, and J.W. Schrader. 1984. Ia antigens and associated invariant chain are induced simultaneously in lines of T-dependent mast cells by recombinant interferon gamma. J. Immunol. 132: 1361-1369.

Koch, N., M.S. Sandrin, G.J. Hämmerling, N. Tada, S. Kimura, and U. Hämmerling. 1984. Monoclonal antibodies detect polymorphic determinants shared by I-A and I-E antigens. Mol. Immunol. 21: 293-299.

Koch, N., and A.W. Harris. 1984. Differential expression of the invariant chain in mouse tumor cells: relationship to B. lymphoid development. J. Immunol. 132: 12-15.

Koch, S., N. Koch, P. Robinson, and G.J. Hämmerling. 1983. Comparison of allogeneic and xenogeneic determinants on the H-2Kk molecule. Transplantation (Baltimore) 36: 177-180.

Rahmsdorf, H.J., N. Koch, U. Mallick, and P. Herrlich. 1983. Regulation of MHC class II invariant chain expression: Induction of synthesis in human and murine plasmacytoma cells by arresting replication. EMBO J. 2: 811-816.

Koch, N., B. Arnold, G.J. Hämmerling, J. Heuer, and E. Kölsch. 1983. Structural comparison of I-A antigens produced by a cloned murine T suppressor cell line with B cell derived I-A. Immunogenetics 17: 497-505.

Koch, S., P.J. Robinson, N. Koch, and G.J. Hämmerling. 1983. Separation of H-2Dd, H-2Ld and H-2Rd by twodimensional gel electrophoresis. Immunogenetics 17: 215-218.

Koch, N., and D. Haustein. 1983. Association of surface IgM with two membrane proteins on murine B lymphocytes detected by chemical crosslinking. Mol. Immunol. 20: 33-37.

Koch, N., and G.J. Hämmerling. 1982. Molecular heterogeneity of Ia antigens: Novel components and complexes. In: Ir Genes: Past, present and future (Eds. C.W. Pierce, S.E. Cullen, J.A. Kapp, B.D. Schwarz, and D.C. Shreffler). Humana Press Inc.: p159-168. 

Koch, N., G.J. Hämmerling, N. Tada, S. Kimura, and U. Hämmerling. 1982. Cross-blocking studies with monoclonal antibodies against I-A molecules of haplotypes b, d and k. Eur. J. Immunol. 12: 909-914.

Koch, N., G.J. Hämmerling, J. Szymura, and M.R. Wabl. 1982. Ia associated Ii chain is not encoded by chromosome 17 of the mouse. Immunogenetics 16: 603-606.

Koch, N., S. Koch, and G.J. Hämmerling. 1982. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody. Nature 299: 644-645.

Hämmerling, G.J., N. Koch, R. Grützmann, and N. Ade. 1982. Monoclonal antibodies against murine Ia antigens: Studies on structure, function, epitopes and idiotypes. In: Ia Antigens. (Eds. S. Ferrone and C.S. David). CRC Press, Boca Raton, Florida: p55-79. 

Koch, N., and G.J. Hämmerling. 1982. Structure of Ia antigens: Identification of dimeric complexes formed by the invariant chain. J. Immunol. 128: 1155-1158.

Koch, N., and D. Haustein. 1982. Subunits of IgM and IgD on the surface of murine B-lymphocytes. Mol. Immunol. 19: 477-485.

Koch, N., and G.J. Hämmerling. 1981. Ia antigens contain two distinct forms of ß chain. Immunogenetics 14: 437-444.

Koch, N., and D. Haustein. 1981. Radioiodination of surface proteins and glycoproteins of lymphocytes by immobilized lactoproxidase. J. Immunol. Meth. 41: 163-171.

Koch, N., and D. Haustein. 1980. The detection of associated erythrocyte membrane proteins by crosslinking and surface radiolabelling. Hoppe-Seyler's Z. Physiol Chem. 361: 885-894.


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